Very Fast Non-dominated Sorting

New and very ecient parallel algorithm for the Fast Non-dominated Sorting of Pareto fronts is proposed. By decreasing its computational complexity, the application of the proposed method allows us to increase the speedup of the best up to now Fast and Elitist Multi-objective Genetic Algorithm (NSGA-II) more than two orders of magnitudes. Formal proofs of time complexities of basic as well as improved versions of the procedure are presented. Provided experimental results fully conrm theoretical ndings

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

Improving the TSAB algorithm through parallel computing

In this paper, a parallel multi-path variant of the well-known TSAB algorithm for the job shop scheduling problem is proposed. Coarse-grained parallelization method is employed, which allows for great scalability of the algorithm with accordance to Gustafon’s law. The resulting P-TSAB algorithm is tested using 162 well-known literature benchmarks. Results indicate that P-TSAB algorithm with a running time of one minute on a modern PC provides solutions comparable to the ones provided by the newest literature approaches to the job shop scheduling problem. Moreover, on average P-TSAB achieves two times smaller percentage relative deviation from the best known solutions than the standard variant of TSAB. The use of parallelization also relieves the user from having to fine-tune the algorithm. The P-TSAB algorithm can thus beused as module in real-life production planning systems or as a local search procedure in other algorithms. It can also provide the upper bound of minimal cycle time for certain problems of cyclic scheduling